The AIR package uses a variety of spatial models to restrict the
type of linear transformation that is being applied when performing
registration. While the most general model could be used in all
instances, to do so would be both unnecessarily slow and in fact,
inaccurate. For example, when if voxel sizes are known exactly, it
makes little sense to use anything other than a rigid-body model for
intrasubject registration unless there are strong reasons to suspect
that the shape and/or size of the brain has changed between image
acquisitions. In this context, any values for the nine extra
parameters that imply anything other than an exact rigid-body fit
might well be considered erroneous.
The following models have been implemented in AIR:
3D linear models
3D nonlinear models
2D linear models
2D nonlinear models
The pages linked above include detailed mathematical descriptions of each model, including explicit listings of the formal parameters of the models and the initialization file format required for each model.